Mignon L Loh Selected Research

pegaspargase (Oncaspar)

10/2021	Favorable Trisomies and ETV6-RUNX1 Predict Cure in Low-Risk B-Cell Acute Lymphoblastic Leukemia: Results From Children's Oncology Group Trial AALL0331.
1/2021	Class II Human Leukocyte Antigen Variants Associate With Risk of Pegaspargase Hypersensitivity.
10/2020	Successful Outcomes of Newly Diagnosed T Lymphoblastic Lymphoma: Results From Children's Oncology Group AALL0434.
10/2020	Children's Oncology Group AALL0434: A Phase III Randomized Clinical Trial Testing Nelarabine in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia.
1/2019	Plasma asparaginase activity and asparagine depletion in acute lymphoblastic leukemia patients treated with pegaspargase on Children's Oncology Group AALL07P4.
10/2018	Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate Randomization.
1/2018	Severe pegaspargase hypersensitivity reaction rates (grade ≥3) with intravenous infusion vs. intramuscular injection: analysis of 54,280 doses administered to 16,534 patients on children's oncology group (COG) clinical trials.
1/2018	Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group.
7/2015	Safe integration of nelarabine into intensive chemotherapy in newly diagnosed T-cell acute lymphoblastic leukemia: Children's Oncology Group Study AALL0434.

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Mignon L Loh Research Topics

Disease

75	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 03/2022 - 02/2007
32	Leukemia 11/2021 - 07/2002
27	Neoplasms (Cancer) 01/2021 - 12/2002
20	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2022 - 08/2010
12	Juvenile Myelomonocytic Leukemia 01/2021 - 05/2012
10	Residual Neoplasm 01/2021 - 06/2011
10	Hypersensitivity (Allergy) 01/2021 - 03/2007
10	Philadelphia Chromosome 01/2021 - 06/2009
5	Noonan Syndrome (Female Pseudo-Turner Syndrome) 11/2016 - 09/2010
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021 - 03/2008
4	Hematologic Neoplasms (Hematological Malignancy) 09/2018 - 01/2016
3	Infections 01/2021 - 03/2015
3	Pancreatitis 01/2018 - 03/2007
3	Neuroblastoma 10/2016 - 12/2004
2	Cytopenia 01/2022 - 01/2018
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2022 - 02/2015
2	Lymphoma (Lymphomas) 01/2022 - 08/2014
2	Hyperbilirubinemia 01/2022 - 01/2021
2	Febrile Neutropenia 01/2021 - 01/2021
2	Genetic Predisposition to Disease (Genetic Predisposition) 11/2019 - 01/2016
2	Osteonecrosis (Kienbock's Disease) 10/2016 - 10/2015
2	Polycythemia Vera 10/2015 - 11/2005
2	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 02/2009 - 04/2006
1	Hyperglycemia 01/2021
1	Sepsis (Septicemia) 01/2021
1	Disease Progression 01/2021
1	Mucositis 01/2021
1	Down Syndrome (Down's Syndrome) 01/2021
1	Central Nervous System Diseases (CNS Diseases) 10/2020
1	Nerve Sheath Neoplasms (Nerve Sheath Neoplasm) 01/2020
1	Plexiform Neurofibroma 01/2020
1	monosomy Chromosome 7 10/2019
1	Chromosome Breakage 01/2019
1	Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive) 01/2019

Drug/Important Bio-Agent (IBA)

12	Phosphotransferases (Kinase)IBA 01/2019 - 03/2004
9	pegaspargase (Oncaspar)FDA Link 10/2021 - 07/2015
9	Asparaginase (Elspar)FDA Link 01/2021 - 03/2007
8	Pharmaceutical PreparationsIBA 01/2021 - 04/2006
8	Methotrexate (Mexate)FDA LinkGeneric 10/2020 - 07/2015
7	Transcription Factors (Transcription Factor)IBA 11/2021 - 09/2014
6	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 03/2008
5	Proteins (Proteins, Gene)FDA Link 06/2021 - 03/2004
5	Biological ProductsIBA 09/2017 - 02/2007
4	Vincristine (Oncovin)FDA LinkGeneric 01/2022 - 02/2015
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022 - 09/2010
4	ChromatinIBA 01/2022 - 11/2019
4	Protein Tyrosine PhosphatasesIBA 11/2016 - 03/2004
4	Tyrosine (L-Tyrosine)FDA Link 02/2016 - 11/2005
3	GlucocorticoidsIBA 01/2022 - 10/2015
3	Inotuzumab OzogamicinIBA 01/2022 - 01/2019
3	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021 - 10/2016
3	nelarabine (506U78)FDA Link 10/2020 - 07/2015
3	Cytokine Receptors (Cytokine Receptor)IBA 06/2019 - 06/2013
3	venetoclaxIBA 01/2019 - 09/2014
3	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2017 - 04/2013
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 05/2015 - 11/2005
2	lestaurtinibIBA 05/2021 - 01/2021
2	HLA Antigens (Human Leukocyte Antigens)IBA 01/2021 - 08/2014
2	Leucovorin (Folinic Acid)FDA Link 10/2020 - 10/2018
2	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2019 - 08/2017
2	CytokinesIBA 06/2019 - 09/2013
2	Dasatinib (BMS 354825)FDA Link 01/2018 - 01/2017
2	Tyrosine Kinase InhibitorsIBA 01/2018 - 09/2014
2	Ikaros Transcription FactorIBA 01/2018 - 06/2009
2	AntibodiesIBA 01/2018 - 08/2014
2	Protein Isoforms (Isoforms)IBA 09/2017 - 12/2016
2	ruxolitinibIBA 10/2015 - 10/2012
2	Janus KinasesIBA 02/2015 - 09/2011
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2013 - 03/2004
2	Rituximab (Mabthera)FDA Link 02/2009 - 04/2006
2	Inosine Triphosphate (ITP)IBA 02/2009 - 04/2006
1	Bortezomib (Velcade)FDA Link 01/2022
1	Proteasome InhibitorsIBA 01/2022
1	tofacitinibIBA 01/2022
1	TransposasesIBA 01/2021
1	HLA-DQB1 antigen (HLA DQB1)IBA 01/2021
1	Transaminases (Aminotransferases)IBA 01/2021
1	AntigensIBA 01/2021
1	Prednisone (Sone)FDA LinkGeneric 01/2021
1	blinatumomabIBA 01/2021
1	Genetic Markers (Genetic Marker)IBA 01/2021
1	AZD 6244IBA 01/2020
1	ElementsIBA 12/2019
1	Azacitidine (5 Azacytidine)FDA Link 10/2019
1	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2019
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2019
1	Essential Amino AcidsIBA 01/2019
1	AsparagineIBA 01/2019
1	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 01/2019
1	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 01/2019
1	Etoposide (VP 16)FDA LinkGeneric 01/2019

Therapy/Procedure

44	Therapeutics 03/2022 - 12/2004
29	Drug Therapy (Chemotherapy) 01/2022 - 07/2002
7	Hematopoietic Stem Cell Transplantation 01/2022 - 01/2015
3	Combination Drug Therapy (Combination Chemotherapy) 11/2020 - 10/2016
2	Stem Cell Transplantation 01/2021 - 11/2016
2	Cranial Irradiation 10/2018 - 01/2018
2	Induction Chemotherapy 01/2018 - 08/2010
2	Cell Transplantation 01/2018 - 01/2014
1	Art Therapy 01/2020